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By Intermission· 2,465 words

Sep 4, 2026

ResearchEvidenceQuestion

Why do pancreatic beta cells fail—and can we preserve or restore them permanently?

Evidence(0)

No evidence timeline has been published for this question yet.

Sources

1.
JCI - β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes
2.
A Brief Review of the Mechanisms of β-Cell Dedifferentiation in Type 2 Diabetes - PMC
3.
Islet β cell failure in type 2 diabetes - PMC
4.
Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis | Endocrinology | Oxford Academic
5.
Type 2 Diabetes: The Pathologic Basis of Reversible β-Cell Dysfunction | Diabetes Care | American Diabetes Association
6.
Time Course of Normalization of Functional β-Cell Capacity in the Diabetes Remission Clinical Trial After Weight Loss in Type 2 Diabetes - PubMed
7.
5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study - PubMed
8.
Decoding the immune dance: Unraveling the interplay between beta cells and type 1 diabetes - PMC
9.
Teplizumab: The First Treatment to Delay the Progression of Type 1 Diabetes - PMC
10.
Teplizumab and β-Cell Function in Newly Diagnosed Type 1 Diabetes | New England Journal of Medicine
11.
Monogenic Defects of Beta Cell Function: From Clinical Suspicion to Genetic Diagnosis and Management of Rare Types of Diabetes - PMC
12.
Human β-cell regeneration: progress, hurdles, and controversy - PMC
13.
Islet Transplantation in Type 1 Diabetes: Ongoing Challenges, Refined Procedures, and Long-Term Outcome - PMC
14.
FDA Approves First Cellular Therapy to Treat Patients with Type 1 Diabetes | FDA
15.
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | New England Journal of Medicine
16.
Vertex Pharmaceuticals | Vertex Announces Program Updates for Type 1 Diabetes Portfolio

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